My question is if the position location to the 2X Ø.126 holes are affected by the movement of the Ø.281 hole the [.150] basic comes off of?
They are not... The 2X Ø.126 holes are probably related to whatever the datums are specified within the associated feature control frame.
The Ø.281 hole can move all over within the specified tolerance as it is related to the specified datums..
Basic dimensions are considered tolerance-less.
Can you post the complete specification for both hole features?